PMID:17851079
| Citation |
Falconer, RA and Toth, I (2007) Design, synthesis and biological evaluation of novel lipoamino acid-based glycolipids for oral drug delivery. Bioorg. Med. Chem. 15:7012-20 |
|---|---|
| Abstract |
A series of lipoamino acid-based glycolipids were synthesised. Suitably derivatised lipoamino acid derivatives were prepared and conjugated to monosaccharides (including glycosyl azides, isothiocyanates, thiols and sulphones) to yield novel O-, N-, S- and C-linked glycolipids in good yields. Their potential to improve the oral absorption of piperacillin is reported. |
| Links |
PubMed Online version:10.1016/j.bmc.2007.07.048 |
| Keywords |
Administration, Oral; Amino Acids/chemical synthesis; Amino Acids/chemistry; Bacillus subtilis/drug effects; Caco-2 Cells; Chromatography, Liquid/methods; Drug Delivery Systems; Drug Design; Enterobacter aerogenes/drug effects; Escherichia coli/drug effects; Glycolipids/chemical synthesis; Glycolipids/chemistry; Glycolipids/pharmacology; Humans; Microbial Sensitivity Tests; Molecular Structure; Monosaccharides/chemistry; Piperacillin/chemical synthesis; Piperacillin/chemistry; Piperacillin/pharmacology; Pseudomonas aeruginosa/drug effects; Staphylococcus aureus/drug effects; Structure-Activity Relationship; Tandem Mass Spectrometry/methods |
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