PMID:17767732

Citation	Fani, R, Brilli, M, Fondi, M and Lió, P (2007) The role of gene fusions in the evolution of metabolic pathways: the histidine biosynthesis case. BMC Evol. Biol. 7 Suppl 2:S4
Abstract	Histidine biosynthesis is one of the best characterized anabolic pathways. There is a large body of genetic and biochemical information available, including operon structure, gene expression, and increasingly larger sequence databases. For over forty years this pathway has been the subject of extensive studies, mainly in Escherichia coli and Salmonella enterica, in both of which details of histidine biosynthesis appear to be identical. In these two enterobacteria the pathway is unbranched, includes a number of unusual reactions, and consists of nine intermediates; his genes are arranged in a compact operon (hisGDC [NB]HAF [IE]), with three of them (hisNB, hisD and hisIE) coding for bifunctional enzymes. We performed a detailed analysis of his gene fusions in available genomes to understand the role of gene fusions in shaping this pathway.
Links	PubMed PMC1963479 Online version:10.1186/1471-2148-7-S2-S4
Keywords	Amino Acid Sequence; Archaea/genetics; Archaea/metabolism; Bacteria/genetics; Bacteria/metabolism; Base Sequence; Eukaryotic Cells; Evolution, Molecular; Gene Duplication; Gene Fusion; Genes, Archaeal; Genes, Bacterial; Histidine/biosynthesis; Histidine/genetics; Metabolic Networks and Pathways/genetics; Phylogeny; Sequence Alignment
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