PMID:17764545

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Citation

Kehrer, D, Ahmed, H, Brinkmann, H and Siebers, B (2007) Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax: new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes. BMC Genomics 8:301

Abstract

The presence of the branched Entner-Doudoroff (ED) pathway in two hyperthermophilic Crenarchaea, the anaerobe Thermoproteus tenax and the aerobe Sulfolobus solfataricus, was suggested. However, so far no enzymatic information of the non-phosphorylative ED branch and especially its key enzyme - glycerate kinase - was available. In the T. tenax genome, a gene homolog with similarity to putative hydroxypyruvate reductase/glycerate dehydrogenase and glycerate kinase was identified.

Links

PubMed PMC2063504 Online version:10.1186/1471-2164-8-301

Keywords

Adenosine Triphosphate/metabolism; Amino Acid Sequence; Catalysis; Molecular Sequence Data; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors; Phosphotransferases (Alcohol Group Acceptor)/classification; Phosphotransferases (Alcohol Group Acceptor)/genetics; Phosphotransferases (Alcohol Group Acceptor)/metabolism; Phylogeny; Recombinant Proteins/antagonists & inhibitors; Recombinant Proteins/classification; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Sequence Homology, Amino Acid; Substrate Specificity; Thermoproteus/enzymology

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