PMID:17716738

Citation	Ragsdale, SW (2007) Nickel and the carbon cycle. J. Inorg. Biochem. 101:1657-66
Abstract	This article, dedicated to Edward Stiefel, reviews three nickel enzymes that play important roles in the carbon cycle: CO dehydrogenase, acetyl-CoA synthase, and methyl-coenzyme M reductase. After a short discussion of the carbon cycle, the structures of the active centers of the proteins and their proposed mechanisms are discussed. A brief description of future research areas is presented for each enzyme system. A short perspective on future research on nickel enzymes ends this contribution.
Links	PubMed PMC2100024 Online version:10.1016/j.jinorgbio.2007.07.014
Keywords	Acetate-CoA Ligase/chemistry; Acetate-CoA Ligase/metabolism; Aldehyde Oxidoreductases/chemistry; Aldehyde Oxidoreductases/metabolism; Binding Sites; Carbon/chemistry; Carbon/metabolism; Models, Biological; Multienzyme Complexes/chemistry; Multienzyme Complexes/metabolism; Nickel/chemistry; Nickel/metabolism; Oxidoreductases/chemistry; Oxidoreductases/metabolism
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