PMID:17688441
| Citation |
Ahmed, A, Frey, G and Michel, CJ (2007) Frameshift signals in genes associated with the circular code. In Silico Biol. (Gedrukt) 7:155-68 |
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| Abstract |
Three sets of 20 trinucleotides are preferentially associated with the reading frames and their 2 shifted frames of both eukaryotic and prokaryotic genes. These 3 sets are circular codes. They allow retrieval of any frame in genes (containing these circular code words), locally anywhere in the 3 frames and in particular without start codons in the reading frame, and automatically with the reading of a few nucleotides. The circular code in the reading frame, noted X, which can deduce the 2 other circular codes in the shifted frames by permutation, is the information used for analysing frameshift genes, i. e. genes with a change of reading frame during translation. This work studies the circular code signal around their frameshift sites. Two scoring methods are developed, a function P based on this code X and a function Q based both on this code X and the 4 trinucleotides with identical nucleotides. They detect a significant correlation between the code X and the -1 frameshift signals in both eukaryotic and prokaryotic genes, and the +1 frameshift signals in eukaryotic genes. |
| Links | |
| Keywords |
Animals; Codon/genetics; DNA/genetics; Eukaryotic Cells/physiology; Frameshifting, Ribosomal; Genes/physiology; Genetic Code; Humans; Models, Genetic; Prokaryotic Cells/physiology |
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