PMID:17510665

Citation	Alon, U (2007) Network motifs: theory and experimental approaches. Nat. Rev. Genet. 8:450-61
Abstract	Transcription regulation networks control the expression of genes. The transcription networks of well-studied microorganisms appear to be made up of a small set of recurring regulation patterns, called network motifs. The same network motifs have recently been found in diverse organisms from bacteria to humans, suggesting that they serve as basic building blocks of transcription networks. Here I review network motifs and their functions, with an emphasis on experimental studies. Network motifs in other biological networks are also mentioned, including signalling and neuronal networks.
Links	PubMed Online version:10.1038/nrg2102
Keywords	Animals; Bacteria/genetics; Bacteria/metabolism; Biological Evolution; Fungi/genetics; Fungi/metabolism; Gene Expression Regulation; Homeostasis; Humans; Models, Genetic; Regulon/genetics; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription, Genetic
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Alon reviews common regulatory circuits and discusses how they affect the expression patterns for the genes they control.

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