PMID:1729222
| Citation |
Mulder, E, Woldringh, CL, Tétart, F and Bouché, JP (1992) New minC mutations suggest different interactions of the same region of division inhibitor MinC with proteins specific for minD and dicB coinhibition pathways. J. Bacteriol. 174:35-9 |
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| Abstract |
Proper positioning of division sites in Escherichia coli requires balanced expression of minC, minD, and minE gene products. Previous genetic analysis has shown that either MinD or an apparently unrelated protein, DicB, cooperates with MinC to inhibit division. We have isolated and sequenced minC mutations that suppress division inhibition caused by overproduction of either DicB or MinD proteins. Most missense mutations were located in the amino acid 160 to 200 region of MinC (231 amino acids). Some mutations exhibited preferential resistance to one or the other coinhibitor, suggesting that two distinct proteins, possibly MinD and DicB themselves, interact in slightly different manners with the same region of MinC to promote division inhibition. |
| Links | |
| Keywords |
Bacterial Proteins/genetics; Cell Division/genetics; Chromosome Mapping; DNA Mutational Analysis; DNA-Binding Proteins/genetics; Escherichia coli/genetics; Gene Expression Regulation, Bacterial; L Forms/genetics; Models, Biological; Phenotype |
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