PMID:17274812
| Citation |
Koss, DJ, Hindley, KP, David, KC, Mancini, I, Guella, G, Sepcić, K, Turk, T, Rebolj, K, Riedel, G, Platt, B and Scott, RH (2007) A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurones. BMC Pharmacol. 7:1 |
|---|---|
| Abstract |
Polymeric alkylpyridinium salts (poly-APS), are chemical defences produced by marine sponges including Reniera sarai. Poly-APS have previously been shown to effectively deliver macromolecules into cells. The efficiency of this closely follows the ability of poly-APS to form transient pores in membranes, providing strong support for a pore-based delivery mechanism. Recently, water soluble compounds have been synthesised that are structurally related to the natural polymers but bear a different number of pyridinium units. These compounds may share a number of bio-activities with poly-APS. Using electrophysiology, calcium imaging and 1,6-diphenyl-1,3,5-hexatriene imaging, the pore forming properties of poly-APS and four related synthetic oligomers have been tested on primary cultured rat hippocampal neurones. |
| Links |
PubMed PMC1797161 Online version:10.1186/1471-2210-7-1 |
| Keywords |
Action Potentials/drug effects; Animals; Animals, Newborn; Calcium/metabolism; Cells, Cultured; Hippocampus/cytology; Liposomes; Membrane Fluidity/drug effects; Molecular Structure; Neurons/drug effects; Neurons/metabolism; Neurons/physiology; Polymers/chemistry; Polymers/isolation & purification; Polymers/pharmacology; Porifera/chemistry; Pyridinium Compounds/chemistry; Pyridinium Compounds/isolation & purification; Pyridinium Compounds/pharmacology; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Surface Plasmon Resonance |
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