PMID:1720672

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Citation

Wower, J and Zimmermann, RA A consonant model of the tRNA-ribosome complex during the elongation cycle of translation. Biochimie 73:961-9

Abstract

Chemical and photochemical affinity techniques have been used extensively to determine the positions of the tRNA binding sites on the Escherichia coli ribosome. Recent advances in our understanding of ribosome structure and function prompted us to critically review the data that have accumulated on tRNA-ribosome cross-links. As a result, we propose a new model of the tRNA-ribosome complex that accounts for nearly all of the pertinent evidence.

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Keywords

Binding Sites; Cross-Linking Reagents; Escherichia coli/genetics; Escherichia coli/metabolism; Models, Biological; Peptide Chain Elongation, Translational; Protein Biosynthesis; RNA, Bacterial/genetics; RNA, Bacterial/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Transfer/genetics; RNA, Transfer/metabolism; Ribosomes/metabolism; Ribosomes/ultrastructure

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