PMID:1713477

Citation	Ulrich, AK, Li, LY and Parker, J (1991) Codon usage, transfer RNA availability and mistranslation in amino acid starved bacteria. Biochim. Biophys. Acta 1089:362-6
Abstract	The fidelity of codon reading was examined in amino acid starved Escherichia coli. In one case the level of misincorporation of methionine was measured at an isoleucine residue encoded by either the commonly used AUU codon or the rarely used AUA codon. In this situation we found the frequency of methionine misincorporation to be very low and to be unaffected by the identity of the isoleucine codon. In other experiments histidine misincorporation for glutamine was measured in glutamine starved cells with normal levels of histidine-specific tRNA and cells overproducing this tRNA. Cells overproducing the tRNA had higher levels of misincorporation.
Links	PubMed
Keywords	Amino Acid Sequence; Base Sequence; Capsid/genetics; Codon; Electrophoresis, Gel, Two-Dimensional; Escherichia coli/genetics; Escherichia coli/metabolism; Glutamine/metabolism; Isoleucine/genetics; Molecular Sequence Data; Protein Biosynthesis; RNA, Bacterial; RNA, Transfer, His/metabolism
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