PMID:17007972

Citation	Slotved, HC, Jacobsen, JN, Møller, HK and Krogfelt, KA (2007) Developing an ELISA using serotype-specific antigens from selected pneumococcal strains of own selection. Vaccine 25:2513-7
Abstract	Streptococcus pneumoniae (pneumococcus) is a significant cause of morbidity and mortality in infants and elderly people. Pneumococcal strains possess a polysaccharide capsule, and 90 different serotypes have been identified. The pneumococcal ELISA suggested by World Health Organization (WHO) guidelines is based on capsular serotypes included in the 23-valent polysaccharide vaccine (Pneumovax((R))). Pneumococcal antigens were developed and applied in an ELISA, which elicited a low baseline cross-reaction with the common cell wall polysaccharide (C-Ps). The aim of this study was to develop an ELISA using type-specific antigens from S. pneumoniae strains with serotypes of own selection in order to quantify type-specific pneumococcal antibodies in human serum.
Links	PubMed Online version:10.1016/j.vaccine.2006.09.028
Keywords	Antibodies, Bacterial/blood; Antibodies, Bacterial/immunology; Antigens, Bacterial/immunology; Bacterial Capsules/immunology; Enzyme-Linked Immunosorbent Assay/methods; Epitopes; Humans; Polysaccharides, Bacterial/immunology; Serotyping; Streptococcus pneumoniae/classification; Streptococcus pneumoniae/immunology
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