PMID:16935877
| Citation |
Killoran, MP and Keck, JL (2006) Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res. 34:4098-105 |
|---|---|
| Abstract |
Helicases are specialized molecular motors that separate duplex nucleic acids into single strands. The RecQ family of helicases functions at the interface of DNA replication, recombination and repair in bacterial and eukaryotic cells. They are key, multifunctional enzymes that have been linked to three human diseases: Bloom's, Werner's and Rothmund-Thomson's syndromes. This review summarizes recent studies that relate the structures of RecQ proteins to their biochemical activities. |
| Links |
PubMed PMC1616949 Online version:10.1093/nar/gkl538 |
| Keywords |
Adenosine Triphosphatases/chemistry; Adenosine Triphosphatases/genetics; Adenosine Triphosphatases/metabolism; Adenosine Triphosphate/metabolism; Bloom Syndrome/genetics; DNA Helicases/chemistry; DNA Helicases/genetics; DNA Helicases/metabolism; DNA Replication/physiology; Humans; Hydrolysis; Protein Structure, Tertiary/physiology; RecQ Helicases; Rothmund-Thomson Syndrome/genetics; Werner Syndrome/genetics |
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