PMID:169229
| Citation |
Justesen, J and Neuhard, J (1975) pyrR identical to pyrH in Salmonella typhimurium: control of expression of the pyr genes. J. Bacteriol. 123:851-4 |
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| Abstract |
Mutants of Salmonella typhimurium showing constitutive synthesis of the pyrimidine biosynthetic enzymes coded for by the pyrA-F genes (G. A. O'Donavan and J. C. Gerhart, 1972) have been reinvestigated. The high rate of expression of the pyrB-F genes in these mutants as well as their pyrimidine excretion is shown to be due to mutations in the gene pyrH encoding uridine 5'-monophosphate kinase. Thus, the term pyrR used for these mutants should be replaced by the designation pyrH. |
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| Keywords |
Aspartate Carbamoyltransferase/biosynthesis; Enzyme Repression; Genes; Genes, Regulator; Mutation; Phosphotransferases/biosynthesis; Pyrimidines/biosynthesis; Salmonella typhimurium/drug effects; Salmonella typhimurium/enzymology; Uridine/analogs & derivatives; Uridine/pharmacology; Uridine Kinase/biosynthesis |
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