PMID:1691451
| Citation |
Göransson, M, Sondén, B, Nilsson, P, Dagberg, B, Forsman, K, Emanuelsson, K and Uhlin, BE (1990) Transcriptional silencing and thermoregulation of gene expression in Escherichia coli. Nature 344:682-5 |
|---|---|
| Abstract |
Expression of specific adhesive properties by bacteria in general seems to be regulated to fit the environmental conditions. An example is the transcriptional regulation of digalactoside-specific binding by uropathogenic strains of Escherichia coli. The fimbrial structures (pili) on the bacterial surface carry the adhesin and are present during growth at 37 degrees C but are not produced by cells at lower temperatures, such as 25 degrees C. Thermoregulation of expression is due to temperature-dependent transcription of a regulatory cistron in the pilus-adhesin gene cluster. We have now identified and characterized a new regulatory locus (drdX) and show that a histone-like bacterial protein has an important role in this novel example of thermoregulation of transcription. |
| Links |
PubMed Online version:10.1038/344682a0 |
| Keywords |
Adhesins, Bacterial; Amino Acid Sequence; Bacterial Adhesion/genetics; Cloning, Molecular; DNA, Bacterial/genetics; Escherichia coli/genetics; Escherichia coli/ultrastructure; Fimbriae, Bacterial/physiology; Gene Expression Regulation, Bacterial; Genes, Bacterial; Hot Temperature; Molecular Sequence Data; Mutation; Operon; Polysaccharides, Bacterial/genetics; RNA, Bacterial/metabolism; RNA, Messenger/metabolism; Regulatory Sequences, Nucleic Acid; Restriction Mapping; Transcription, Genetic |
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