PMID:1691435
| Citation |
Masters, M, March, JB, Oliver, IR and Collins, JF (1990) A possible role for the pcnB gene product of Escherichia coli in modulating RNA: RNA interactions. Mol. Gen. Genet. 220:341-4 |
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| Abstract |
The sequence of the PcnB protein of Escherichia coli, a protein required for copy number maintenance of ColE1-related plasmids, was compared with the PIR sequence database. Strong local similarities to the sequence of the E. coli protein tRNA nucleotidyltransferase were found. Since a substrate of the latter protein, tRNA, structurally resembles the RNAs that control ColE1 copy number we believe that we may have identified a region in PcnB that interacts with these RNAs. Consistent with this idea is our observation that PcnB is required for the replication of R1, a plasmid whose replication is also regulated by a small RNA. |
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| Keywords |
Amino Acid Sequence; Bacterial Proteins/genetics; Bacteriocin Plasmids; DNA Replication; Escherichia coli/genetics; Escherichia coli Proteins; Molecular Sequence Data; Plasmids; Polynucleotide Adenylyltransferase; RNA Nucleotidyltransferases/genetics; RNA, Bacterial/metabolism; Sequence Homology, Nucleic Acid |
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