PMID:16885328
| Citation |
Beekwilder, J, Wolswinkel, R, Jonker, H, Hall, R, de Vos, CH and Bovy, A (2006) Production of resveratrol in recombinant microorganisms. Appl. Environ. Microbiol. 72:5670-2 |
|---|---|
| Abstract |
Resveratrol production in Saccharomyces cerevisiae was compared to that in Escherichia coli. In both systems, 4-coumarate:coenzyme A ligase from tobacco and stilbene synthase from grapes were expressed. When p-coumaric acid was used as the precursor, resveratrol accumulations in the culture medium were observed to be comparable in E. coli (16 mg/liter) and yeast (6 mg/liter). |
| Links |
PubMed PMC1538726 Online version:10.1128/AEM.00609-06 |
| Keywords |
Acyltransferases/genetics; Acyltransferases/metabolism; Biotechnology/methods; Coenzyme A Ligases/genetics; Coenzyme A Ligases/metabolism; Coumaric Acids/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/metabolism; Recombination, Genetic; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Stilbenes/metabolism; Tobacco/enzymology; Tobacco/genetics; Vitis/genetics; Vitis/metabolism |
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