PMID:16848900

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Citation

Purta, E, van Vliet, F, Tkaczuk, KL, Dunin-Horkawicz, S, Mori, H, Droogmans, L and Bujnicki, JM (2006) The yfhQ gene of Escherichia coli encodes a tRNA:Cm32/Um32 methyltransferase. BMC Mol. Biol. 7:23

Abstract

Naturally occurring tRNAs contain numerous modified nucleosides. They are formed by enzymatic modification of the primary transcripts during the complex RNA maturation process. In model organisms Escherichia coli and Saccharomyces cerevisiae most enzymes involved in this process have been identified. Interestingly, it was found that tRNA methylation, one of the most common modifications, can be introduced by S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases (MTases) that belong to two structurally and phylogenetically unrelated protein superfamilies: RFM and SPOUT.

Links

PubMed PMC1569432 Online version:10.1186/1471-2199-7-23

Keywords

Escherichia coli Proteins/physiology; Eukaryotic Cells; Methylation; Prokaryotic Cells; RNA, Transfer/metabolism; Terminology as Topic; tRNA Methyltransferases/genetics; tRNA Methyltransferases/metabolism; tRNA Methyltransferases/physiology

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