PMID:16793958
| Citation |
Möhlig, M, Jürgens, A, Spranger, J, Hoffmann, K, Weickert, MO, Schlösser, HW, Schill, T, Brabant, G, Schüring, A, Pfeiffer, AF, Gromoll, J and Schöfl, C (2006) The androgen receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic ovary syndrome. Eur. J. Endocrinol. 155:127-30 |
|---|---|
| Abstract |
Hyperandrogenism is a central feature of the polycystic ovary syndrome (PCOS) and might worsen insulin resistance (IR) often seen in PCOS. Androgens act through the androgen receptor (AR). A polymorphic CAG repeat sequence within the AR gene was reported to modulate its transactivation activity. Therefore, we investigated a putative interaction between testosterone and the CAG repeat length polymorphism with respect to IR. |
| Links |
PubMed Online version:10.1530/eje.1.02195 |
| Keywords |
Adult; Alleles; Cohort Studies; Female; Glucose Tolerance Test; Homeostasis/physiology; Humans; Insulin Resistance/physiology; Polycystic Ovary Syndrome/genetics; Polycystic Ovary Syndrome/physiopathology; Polymorphism, Restriction Fragment Length; Receptors, Androgen/genetics; Regression Analysis; Repetitive Sequences, Nucleic Acid; Testosterone/blood; Testosterone/physiology |
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