PMID:16737554
| Citation |
Mau, B, Glasner, JD, Darling, AE and Perna, NT (2006) Genome-wide detection and analysis of homologous recombination among sequenced strains of Escherichia coli. Genome Biol. 7:R44 |
|---|---|
| Abstract |
Comparisons of complete bacterial genomes reveal evidence of lateral transfer of DNA across otherwise clonally diverging lineages. Some lateral transfer events result in acquisition of novel genomic segments and are easily detected through genome comparison. Other more subtle lateral transfers involve homologous recombination events that result in substitution of alleles within conserved genomic regions. This type of event is observed infrequently among distantly related organisms. It is reported to be more common within species, but the frequency has been difficult to quantify since the sequences under comparison tend to have relatively few polymorphic sites. |
| Links |
PubMed PMC1779527 Online version:10.1186/gb-2006-7-5-r44 |
| Keywords |
Alleles; Base Sequence; Escherichia coli/genetics; Gene Transfer, Horizontal; Genes, Bacterial; Genome, Bacterial; Genomics; Molecular Sequence Data; Operon; Phylogeny; Polymorphism, Genetic; Recombination, Genetic; Sequence Alignment; Shigella flexneri/genetics |
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