PMID:1667478
| Citation |
Saier, MH Jr (1991) A multiplicity of potential carbon catabolite repression mechanisms in prokaryotic and eukaryotic microorganisms. New Biol. 3:1137-47 |
|---|---|
| Abstract |
The discovery of cyclic AMP (cAMP) and its receptor protein in Escherichia coli and the convincing demonstration that these molecules mediate catabolite repression of the synthesis of carbohydrate catabolic enzymes led to the widespread belief that the phenomenon of catabolite repression in bacteria was understood. It is now recognized that cAMP-independent catabolite repression mechanisms are operative in both prokaryotic and eukaryotic microorganisms. New evidence has led to the identification of a diversity of cAMP-independent regulatory mechanisms that may mediate catabolite repression in bacteria. These mechanisms utilize (i) novel transcription factors, (ii) starvation-induced RNA polymerase sigma factors, and (iii) three evolutionarily distinct protein phosphorylating enzyme systems. Although these mechanisms are not fully understood, it is suggested that they exert their effects at the transcriptional level and that phosphorylation and allosteric control by regulatory proteins are involved in these processes. |
| Links | |
| Keywords |
Bacteria/metabolism; Bacterial Proteins; Cyclic AMP/metabolism; DNA-Binding Proteins/physiology; Escherichia coli Proteins; Eukaryotic Cells/metabolism; Gene Expression Regulation, Bacterial/physiology; Gene Expression Regulation, Enzymologic/physiology; Membrane Transport Proteins/metabolism; Phosphoenolpyruvate Sugar Phosphotransferase System/physiology; Prokaryotic Cells/metabolism; Repressor Proteins/physiology; Spores, Bacterial/physiology; Transcription Factors/metabolism |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.