PMID:1645125
| Citation |
Plumbridge, JA (1992) A dominant mutation in the gene for the Nag repressor of Escherichia coli that renders the nag regulon uninducible. J. Gen. Microbiol. 138:1011-7 |
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| Abstract |
The gene nagC encodes the repressor for the nag regulon. A point mutation within the gene, which confers a super-repressor phenotype and makes the repressor insensitive to the inducer, N-acetylglucosamine 6-phosphate, has been characterized. The mutation is semi-dominant since heterozygous diploids have reduced growth rates on glucosamine and N-acetylglucosamine compared to the wild-type strain. |
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| Keywords |
Acetylglucosamine/analogs & derivatives; Acetylglucosamine/metabolism; Amidohydrolases/biosynthesis; Amidohydrolases/genetics; Amino Acyl-tRNA Synthetases/genetics; Bacterial Proteins/genetics; Chromosome Mapping; Cloning, Molecular; Diploidy; Enzyme Induction/genetics; Escherichia coli/genetics; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Dominant/genetics; Glucosamine/metabolism; Mutation/genetics; Recombinant Fusion Proteins/biosynthesis; Repressor Proteins/genetics; Transcription Factors; Transduction, Genetic; beta-Galactosidase/biosynthesis |
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