PMID:16428426
| Citation |
van der Sluis, EO, van der Vries, E, Berrelkamp, G, Nouwen, N and Driessen, AJ (2006) Topologically fixed SecG is fully functional. J. Bacteriol. 188:1188-90 |
|---|---|
| Abstract |
It has been proposed that the bitopic membrane protein SecG undergoes topology inversion during translocation of (pre)proteins via SecYEG. Here we show that SecG covalently cross-linked to SecY cannot invert its topology while remaining fully functional in protein translocation. Our results strongly disfavor topology inversion of SecG during protein translocation. |
| Links |
PubMed PMC1347354 Online version:10.1128/JB.188.3.1188-1190.2006 |
| Keywords |
Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Biological Transport/physiology; Escherichia coli Proteins/chemistry; Escherichia coli Proteins/physiology; Membrane Proteins/chemistry; Membrane Proteins/physiology; Membrane Transport Proteins/chemistry; Membrane Transport Proteins/physiology; Protein Transport |
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