PMID:16405963

Citation	Ko, JH, Lee, SJ, Cho, B and Lee, Y (2006) Differential promoter usage of infA in response to cold shock in Escherichia coli. FEBS Lett. 580:539-44
Abstract	Initiation factor 1 (IF1) is an essential protein in Escherichia coli involved in the initiation step of protein synthesis. The protein level of IF1 increases when E. coli cells are subjected to cold shock, however, it remains unclear as to how this increase occurs. The infA gene encoding IF1 contains two promoters, the distal P1 and the proximal P2 promoter. In this study, we found that infA mRNA was greatly increased, and that this increase resulted from transcriptional activation of P1, not P2, during cold shock although stability of transcripts from both promoters concomitantly increased.
Links	PubMed Online version:10.1016/j.febslet.2005.12.066
Keywords	Base Sequence; Cold Temperature; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Prokaryotic Initiation Factor-1/genetics; Prokaryotic Initiation Factor-1/metabolism; Promoter Regions, Genetic; RNA Stability
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