PMID:16377712

Citation	Zhao, X, Malik, M, Chan, N, Drlica-Wagner, A, Wang, JY, Li, X and Drlica, K (2006) Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli. Antimicrob. Agents Chemother. 50:362-4
Abstract	Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.
Links	PubMed PMC1346826 Online version:10.1128/AAC.50.1.362-364.2006
Keywords	Anti-Infective Agents/pharmacology; Bacterial Proteins/genetics; Chloramphenicol/pharmacology; DNA Helicases/genetics; DNA Replication/drug effects; DnaB Helicases; Escherichia coli/drug effects; Escherichia coli/genetics; Mutation; Quinolones/pharmacology; Temperature
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