PMID:16360025

Citation	Vassylyev, DG and Artsimovitch, I (2005) Tracking RNA polymerase, one step at a time. Cell 123:977-9
Abstract	Although the structural analysis of transcription has attained atomic resolution, techniques to manipulate single molecules involved in transcription have lagged behind. A recent paper in Nature by Abbondanzieri et al. (2005) closes this gap. This study finds that individual molecules of bacterial RNA polymerase move in single base-pair steps and concludes that RNA polymerase acts as a Brownian ratchet that is driven forward by the binding of incoming nucleoside triphosphates.
Links	PubMed Online version:10.1016/j.cell.2005.11.030
Keywords	Base Pairing; Binding Sites/genetics; Catalytic Domain/genetics; DNA/genetics; DNA/metabolism; DNA-Directed RNA Polymerases/metabolism; Escherichia coli/enzymology; Models, Biological; Nucleotides/genetics; Nucleotides/metabolism; Templates, Genetic; Transcription, Genetic
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.