PMID:16352851
| Citation |
Matic, I, Ekiert, D, Radman, M and Kohiyama, M (2006) Generation of DNA-free Escherichia coli cells by 2-aminopurine requires mismatch repair and nonmethylated DNA. J. Bacteriol. 188:339-42 |
|---|---|
| Abstract |
Undirected mismatch repair initiated by the incorporation of the base analog 2-aminopurine kills DNA-methylation-deficient Escherichia coli dam cells by DNA double-strand breakage. Subsequently, the chromosomal DNA is totally degraded, resulting in DNA-free cells. |
| Links |
PubMed PMC1317583 Online version:10.1128/JB.188.1.339-342.2006 |
| Keywords |
2-Aminopurine/pharmacology; Antimetabolites/pharmacology; Base Pair Mismatch; DNA Repair; DNA, Bacterial/metabolism; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli Proteins; Flow Cytometry; Site-Specific DNA-Methyltransferase (Adenine-Specific) |
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