PMID:16343907

Citation	Braeken, K, Moris, M, Daniels, R, Vanderleyden, J and Michiels, J (2006) New horizons for (p)ppGpp in bacterial and plant physiology. Trends Microbiol. 14:45-54
Abstract	A hyperphosphorylated guanosine nucleotide, (p)ppGpp, was initially identified as the effector molecule responsible for the stringent response in Escherichia coli. However, a rapidly growing number of reports proves that (p)ppGpp-mediated regulation is conserved in many bacteria and even in plants. It is now clear that (p)ppGpp acts as a global regulator during physiological adaptation of the organism to a plethora of environmental conditions. Adaptation is not only essential for surviving periods of stress and nutrient exhaustion but also for the interaction of bacteria with their eukaryotic host, as observed during pathogenesis and symbiosis, and for bacterial multicellular behaviour. Recently, there have been several new discoveries about the effects of (p)ppGpp levels, balanced by RelA-SpoT homologue proteins, in diverse organisms.
Links	PubMed Online version:10.1016/j.tim.2005.11.006
Keywords	Arabidopsis/physiology; Bacterial Physiological Phenomena; Escherichia coli/physiology; Guanosine Pentaphosphate/physiology; Ligases/physiology; Plant Physiological Phenomena
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.