PMID:16335244
| Citation |
Abrat, OB, Semchyshyn, HM and Lushchak, VI [Effect of alloxan on survival and antioxidant defense of Escherichia coli]. Ukr. Biokhim. Zh. 77:123-9 |
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| Abstract |
The effect of alloxan has been studied on survival and activity of antioxidant and associated enzymes of E. coli wild strains and ones lacked of OxyR and SoxR proteins--regulators of antioxidant defense in E. coli. Bacteria treatment by 500 microM alloxan for 30 min caused an increase of catalase and peroxidase activity in wild and deltasoxRS strains. Catalase activity was not changed in response to alloxan exposure of oxyR deficient strain. It was proposed that under used condition the effect of alloxan on E. coli could be related to the growth of steadystate concentration of hydrogen peroxide. This supposition is also in agreement with the increase of soxRS regulon enzymes activities, because in our previous work it has been shown that H2O2-induced stress increases the activity of some soxRS regulon enzymes. |
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| Keywords |
Alloxan/pharmacology; Antioxidants/metabolism; DNA-Binding Proteins/genetics; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli Proteins/genetics; Hydrogen Peroxide/metabolism; Regulon/genetics; Repressor Proteins/genetics; Trans-Activators/genetics; Transcription Factors/genetics |
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