PMID:16249243

Citation	Bileviciute-Ljungar, I, Saxne, T and Spetea, M (2006) Anti-inflammatory effects of contralateral administration of the kappa-opioid agonist U-50,488H in rats with unilaterally induced adjuvant arthritis. Rheumatology (Oxford) 45:295-302
Abstract	The effect of repeated contralateral treatment with the kappa-opioid receptor agonist U-50,488H {trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benzene acetamide methanesulphonate} was investigated in rats with unilaterally induced adjuvant arthritis.
Links	PubMed Online version:10.1093/rheumatology/kei156
Keywords	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer/administration & dosage; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer/therapeutic use; Analgesics, Non-Narcotic/administration & dosage; Analgesics, Non-Narcotic/therapeutic use; Animals; Ankle Joint/pathology; Antirheumatic Agents/administration & dosage; Antirheumatic Agents/therapeutic use; Arthritis, Experimental/pathology; Arthritis, Experimental/prevention & control; Body Weight; Drug Administration Schedule; Edema/drug therapy; Edema/pathology; Female; Hindlimb/pathology; Pain/prevention & control; Pain Measurement; Rats; Rats, Inbred Lew; Receptors, Opioid, kappa/agonists; Severity of Illness Index
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