PMID:16242564
| Citation |
Chung, AW, Rauniyar, P, Luo, H, Hsiang, YN, van Breemen, C and Okon, EB (2005) Pressure distention compared with pharmacologic relaxation in vein grafting upregulates matrix metalloproteinase-2 and -9. J. Vasc. Surg. 42:747-56 |
|---|---|
| Abstract |
Autogenous vein bypasses are a common and effective method to treat occlusive disease. During surgical preparation, veins are routinely pressure distended to overcome vasospasm and twists. Distention, however, is believed to promote vascular remodeling and contribute to decreased graft patency. Pharmacologic vasorelaxation with a combination of effective vasodilators has been suggested as an alternative to pressure distention. The extracellular matrix (ECM)-degrading matrix metalloproteinases (MMPs) have been implicated in vascular remodeling and neointima formation. The purpose of the present study was to compare the effects of pressure distention with pharmacologic vasorelaxation on graft remodeling and regulation of MMP-2 and MMP-9 in porcine vein grafts. |
| Links |
PubMed Online version:10.1016/j.jvs.2005.05.037 |
| Keywords |
Animals; Biological Markers/analysis; Biopsy, Needle; Blotting, Western; Carotid Stenosis/surgery; Dilatation, Pathologic; Disease Models, Animal; Female; Hemodynamics/physiology; Immunohistochemistry; Jugular Veins/transplantation; Matrix Metalloproteinase 2/analysis; Matrix Metalloproteinase 2/metabolism; Matrix Metalloproteinase 9/analysis; Matrix Metalloproteinase 9/metabolism; Phenoxybenzamine/pharmacology; Probability; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction/methods; Sensitivity and Specificity; Swine; Tissue Preservation; Tissue Transplantation/methods; Transplantation, Autologous; Up-Regulation; Vascular Surgical Procedures/methods |
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