PMID:16238627
| Citation |
Wang, S, Arends, SJ, Weiss, DS and Newman, EB (2005) A deficiency in S-adenosylmethionine synthetase interrupts assembly of the septal ring in Escherichia coli K-12. Mol. Microbiol. 58:791-9 |
|---|---|
| Abstract |
A mutant in which S-adenosylmethionine synthetase is underexpressed makes filaments with no visible septa. Examination with GFP fusions to various septal proteins shows that FtsZ, ZipA and FtsA localize to the septal ring, but FtsQ, FtsW, FtsI or FtsN do not. The requirement for S-adenosylmethionine suggests that some methylation reaction is required before a complete septal ring can be assembled. |
| Links |
PubMed Online version:10.1111/j.1365-2958.2005.04864.x |
| Keywords |
Anti-Bacterial Agents/pharmacology; Aztreonam/pharmacology; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cell Division/physiology; Cytoskeleton/metabolism; Escherichia coli K12/cytology; Escherichia coli K12/drug effects; Escherichia coli K12/genetics; Escherichia coli K12/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Methionine Adenosyltransferase/genetics; Methionine Adenosyltransferase/metabolism; Methylation; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; S-Adenosylmethionine/metabolism |
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