PMID:16166552

Citation	Kuban, W, Banach-Orlowska, M, Bialoskorska, M, Lipowska, A, Schaaper, RM, Jonczyk, P and Fijalkowska, IJ (2005) Mutator phenotype resulting from DNA polymerase IV overproduction in Escherichia coli: preferential mutagenesis on the lagging strand. J. Bacteriol. 187:6862-6
Abstract	We investigated the mutator effect resulting from overproduction of Escherichia coli DNA polymerase IV. Using lac mutational targets in the two possible orientations on the chromosome, we observed preferential mutagenesis during lagging strand synthesis. The mutator activity likely results from extension of mismatches produced by polymerase III holoenzyme.
Links	PubMed PMC1251572 Online version:10.1128/JB.187.19.6862-6866.2005
Keywords	DNA Polymerase III/genetics; DNA Polymerase beta/genetics; DNA Replication/genetics; DNA, Bacterial/genetics; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins/genetics; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Mutagenesis/genetics; Phenotype
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