PMID:16139196

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Citation

Ellis, RJ (2005) Chaperomics: in vivo GroEL function defined. Curr. Biol. 15:R661-3

Abstract

A recent proteome analysis of protein folding inside cells of Escherichia coli predicts that only 84 of the approximately 2400 cytosolic proteins expressed in minimal media depend absolutely on the GroEL/GroES chaperone system to avoid aggregation. These proteins are enriched in alpha/beta domains and 13 are essential for growth.

Links

PubMed Online version:10.1016/j.cub.2005.08.025

Keywords

Bacterial Proteins/metabolism; Chaperonin 60/metabolism; Cytosol/metabolism; Escherichia coli/metabolism; Models, Biological; Molecular Chaperones/metabolism; Multiprotein Complexes/metabolism; Protein Binding; Protein Folding; Proteomics/methods

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