PMID:16109926

Citation	Suzuki, H, Koyanagi, T, Izuka, S, Onishi, A and Kumagai, H (2005) The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette. J. Bacteriol. 187:5861-7
Abstract	Glutathione protects cells and organisms from oxygen species and peroxides and is indispensable for aerobically living organisms. Moreover, it acts against xenobiotics and drugs by the formation and excretion of glutathione S conjugates. In this study, we show that the yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a glutathione transporter with the ATP-binding cassette. The transporter imports extracellular glutathione into the cytoplasm in an ATP-dependent manner. This transporter, along with gamma-glutamyltranspeptidase, has an important role in E. coli growth with glutathione as a sole sulfur source.
Links	PubMed PMC1196167 Online version:10.1128/JB.187.17.5861-5867.2005
Keywords	ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Base Sequence; Cytoplasm/metabolism; DNA Primers; Escherichia coli K12/genetics; Escherichia coli K12/metabolism; Glutamic Acid/metabolism; Kinetics; Molecular Sequence Data; Mutagenesis; Plasmids; Restriction Mapping
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