PMID:16107138

Citation	Lee, AM, Ross, CT, Zeng, BB and Singleton, SF (2005) A molecular target for suppression of the evolution of antibiotic resistance: inhibition of the Escherichia coli RecA protein by N(6)-(1-naphthyl)-ADP. J. Med. Chem. 48:5408-11
Abstract	We report that N(6)-(1-naphthyl)-ADP inhibits the Escherichia coli RecA protein in vitro. A novel rapid screen identified it as a potent inhibitor of RecA nucleoprotein filament formation, and further characterization established it as an ATP-competitive inhibitor of RecA-catalyzed ATP hydrolysis. This and other inhibitors of RecA activities represent a new approach for understanding the molecular targets and pathways involved in the evolution of antibiotic resistance in bacteria.
Links	PubMed Online version:10.1021/jm050113z
Keywords	1-Naphthylamine/analogs & derivatives; 1-Naphthylamine/chemical synthesis; 1-Naphthylamine/chemistry; Adenosine Diphosphate/analogs & derivatives; Adenosine Diphosphate/chemical synthesis; Adenosine Diphosphate/chemistry; Adenosine Triphosphate/chemistry; DNA, Single-Stranded/chemistry; Drug Resistance, Bacterial; Escherichia coli Proteins/chemistry; Hydrolysis; Kinetics; Models, Molecular; Protein Binding; Rec A Recombinases/antagonists & inhibitors; Rec A Recombinases/chemistry; Structure-Activity Relationship
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