PMID:1608979
| Citation |
Normanly, J, Ollick, T and Abelson, J (1992) Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA. Proc. Natl. Acad. Sci. U.S.A. 89:5680-4 |
|---|---|
| Abstract |
Each aminoacyl-tRNA synthetase must functionally distinguish its cognate tRNAs from all others. We have determined the minimum number of changes required to transform a leucine amber suppressor tRNA to serine identity. Eight changes are required. These are located in the acceptor stem and in the D stem. |
| Links | |
| Keywords |
Base Composition; Base Sequence; Escherichia coli/genetics; Genes, Synthetic; Genetic Variation; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Plasmids; RNA, Transfer, Leu/genetics; RNA, Transfer, Ser/genetics; Suppression, Genetic |
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