PMID:16051792

Citation	Koçer, A, Walko, M, Meijberg, W and Feringa, BL (2005) A light-actuated nanovalve derived from a channel protein. Science 309:755-8
Abstract	Toward the realization of nanoscale device control, we report a molecular valve embedded in a membrane that can be opened by illumination with long-wavelength ultraviolet (366 nanometers) light and then resealed by visible irradiation. The valve consists of a channel protein, the mechanosensitive channel of large conductance (MscL) from Escherichia coli, modified by attachment of synthetic compounds that undergo light-induced charge separation to reversibly open and close a 3-nanometer pore. The system is compatible with a classical encapsulation system, the liposome, and external photochemical control over transport through the channel is achieved.
Links	PubMed Online version:10.1126/science.1114760
Keywords	Amino Acid Substitution; Binding Sites; Cysteine/chemistry; Escherichia coli Proteins/chemistry; Fluoresceins/chemistry; Hydrophobic and Hydrophilic Interactions; Ion Channel Gating; Ion Channels/chemistry; Light; Lipid Bilayers; Liposomes; Nanostructures; Nanotechnology; Osmolar Concentration; Patch-Clamp Techniques; Photolysis; Protein Structure, Secondary; Ultraviolet Rays
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