PMID:15980397

Citation	Tran, JH, Jacoby, GA and Hooper, DC (2005) Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IV. Antimicrob. Agents Chemother. 49:3050-2
Abstract	Purified QnrA blocked ciprofloxacin inhibition of topoisomerase IV, just as QnrA was previously found to prevent quinolone inhibition of DNA gyrase. With a gel displacement assay, tagged QnrA was shown to bind to topoisomerase IV and its subunits in a reaction that did not depend on the presence of DNA, quinolone, or ATP.
Links	PubMed PMC1168640 Online version:10.1128/AAC.49.7.3050-3052.2005
Keywords	Anti-Infective Agents/pharmacology; DNA Topoisomerase IV/metabolism; Drug Resistance, Bacterial/genetics; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Plasmids/genetics; Quinolones/pharmacology
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