PMID:15978695

Citation	Mitchison, G (2005) The regional rule for bacterial base composition. Trends Genet. 21:440-3
Abstract	If one looks at the composition of coding DNA and of three types of intergenic regions--those between convergent, parallel and divergent genes--a striking pattern is seen in a wide range of bacteria. The AT-content of coding sequence is lowest, and the AT-contents of the intergenic regions increase in the order: convergent, parallel and divergent. Why does this pattern occur? In this article, I suggest an explanation based on the structural requirements for the binding of transcription factors.
Links	PubMed Online version:10.1016/j.tig.2005.06.002
Keywords	Bacteria/genetics; Bacteria/metabolism; Bacterial Proteins/metabolism; Base Composition; Binding Sites/genetics; DNA, Bacterial/chemistry; DNA, Bacterial/genetics; DNA, Bacterial/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Genome, Bacterial; Models, Genetic; Nucleic Acid Conformation; Thermodynamics; Transcription Factors/metabolism
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