PMID:15953929

Citation	Krulwich, TA, Lewinson, O, Padan, E and Bibi, E (2005) Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study. Nat. Rev. Microbiol. 3:566-72
Abstract	Drug and multidrug resistance have greatly compromised the compounds that were once the mainstays of antibiotic therapy. This resistance often persists despite reductions in the use of antibiotics, indicating that the proteins encoded by antibiotic-resistance genes have alternative physiological roles that can foster such persistence in the absence of selective pressure by antibiotics. The recent observations that Tet(L), a tetracycline-efflux transporter, and MdfA, a multidrug-efflux transporter, both confer alkali tolerance offer a striking case study in support of this hypothesis.
Links	PubMed Online version:10.1038/nrmicro1181
Keywords	Anti-Bacterial Agents/pharmacology; Antiporters/physiology; Bacteria/drug effects; Bacteria/genetics; Bacteria/metabolism; Drug Resistance, Microbial/genetics; Escherichia coli Proteins/physiology; Membrane Proteins/physiology; Membrane Transport Proteins/physiology; Potassium-Hydrogen Antiporters/physiology; Sodium-Hydrogen Antiporter/physiology; Tetracycline/pharmacology; Tetracycline Resistance/genetics
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.