PMID:15950878

Citation	Semsey, S, Virnik, K and Adhya, S (2005) A gamut of loops: meandering DNA. Trends Biochem. Sci. 30:334-41
Abstract	Nucleoprotein complexes comprising short DNA loops (150 base pairs or less) are involved in a wide variety of DNA transactions (e.g. transcription regulation, replication and recombination) in both prokaryotes and eukaryotes, and also can be useful in designing nanostructures. In these higher-order nucleoprotein complexes, proteins bound to spatially separated sites on a DNA interact with each other by looping out the relatively stiff intervening DNA. Recent technological developments have enabled determination of DNA trajectories in a few DNA-loop-containing regulatory complexes. Results show that, in a given system, a specific DNA trajectory is preferred over others.
Links	PubMed Online version:10.1016/j.tibs.2005.04.009
Keywords	Bacterial Proteins/metabolism; Binding Sites; DNA/chemistry; DNA/metabolism; DNA-Binding Proteins/metabolism; Escherichia coli Proteins/metabolism; Lac Repressors; Nucleic Acid Conformation; Nucleoproteins/metabolism; Proto-Oncogene Proteins c-myb/genetics; Proto-Oncogene Proteins c-myb/metabolism; Repressor Proteins/metabolism
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