PMID:15938389
| Citation |
Smirnova, GV, Torkhova, OA and Oktiabr'skiĭ, ON [The role of antioxidant systems in the response of Escherichia coli to acetamidophenol and some antibiotics]. Mikrobiologiia 74:149-56 |
|---|---|
| Abstract |
The role of glutathione and other antioxidant systems in the response of Escherichia coli to acetamidophenol (paracetamol), rifampicin, and chloramphenicol was studied. The exposure of aerobically growing E. coli cells to acetamidophenol diminished the intracellular level of glutathione by 40% and the reduced-to-oxidized glutathione ratio in the cells by 50%, while it enhanced the expression of the antioxidant genes soxS and sodA by 2.7 and 1.8 times, respectively. Glutathione-deficient cells were more susceptible to acetamidophenol than were normal cells. All this suggests that acetamidophenol induces a mild oxidative stress in E. coli cells. The oxidative stress induced by rifampicin was still less pronounced, whereas chloramphenicol-treated E.coli cells exhibited no signs of oxidative stress at all. |
| Links | |
| Keywords |
Acetaminophen/pharmacology; Analgesics, Non-Narcotic/pharmacology; Anti-Bacterial Agents/pharmacology; Chloramphenicol/pharmacology; Escherichia coli/drug effects; Escherichia coli/metabolism; Escherichia coli/physiology; Escherichia coli Proteins/metabolism; Glutathione/metabolism; Glutathione Disulfide/metabolism; Oxidative Stress; Rifampin/pharmacology; Superoxide Dismutase/metabolism; Trans-Activators/metabolism |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.