PMID:15922599

Citation	Kruse, T and Gerdes, K (2005) Bacterial DNA segregation by the actin-like MreB protein. Trends Cell Biol. 15:343-5
Abstract	Faithful chromosome segregation is vital to all organisms. Eukaryotic cells use the tubulin-based cytoskeleton to segregate their chromosomes during mitosis. A handful of papers have provided convincing evidence that, in bacteria, this task is accomplished by the actin homolog MreB. In particular, a recent study by Gitai et al. demonstrates that MreB specifically binds to and segregates the replication origin of the bacterial chromosome.
Links	PubMed Online version:10.1016/j.tcb.2005.05.002
Keywords	Actins/metabolism; Bacillus subtilis/drug effects; Bacillus subtilis/genetics; Caulobacter crescentus/drug effects; Caulobacter crescentus/genetics; Chromosome Segregation/drug effects; Chromosomes, Bacterial/drug effects; Cytoskeleton/metabolism; DNA, Bacterial/biosynthesis; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli Proteins/metabolism; Replication Origin; Thiourea/analogs & derivatives; Thiourea/pharmacology
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