PMID:15907776

Citation	Bridges, BA (2005) Error-prone DNA repair and translesion DNA synthesis. II: The inducible SOS hypothesis. DNA Repair (Amst.) 4:725-6, 739
Abstract	Evelyn Witkin hypothesized in 1967 that bacterial cell division is controlled by a repressor which, like the lambda repressor, is inactivated by a complex process that starts with the presence of replication-blocking lesions in the DNA. She further suggested that this might not be the only cellular function to show induction by DNA damage. Three years later, Miroslav Radman, in a privately circulated note, proposed that one such function might be an inaccurate (mutation-prone) DNA polymerase under the control of the recA and lexA genes. Thus was born the SOS hypothesis.
Links	PubMed Online version:10.1016/j.dnarep.2004.12.009
Keywords	DNA Repair; DNA Replication; DNA, Bacterial; Dose-Response Relationship, Radiation; Escherichia coli/genetics; Escherichia coli/radiation effects; Gene Expression Regulation, Bacterial; Genes, Bacterial; Mutation; SOS Response (Genetics); Ultraviolet Rays
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