PMID:15895686

Citation	Bernier, S, Dubois, DY, Habegger-Polomat, C, Gagnon, LP, Lapointe, J and Chênevert, R (2005) Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E. coli glutamyl-tRNA synthetase. J Enzyme Inhib Med Chem 20:61-7
Abstract	5'-O-[N-(L-glutamyl)-sulfamoyl] adenosine is a potent competitive inhibitor of E. coli glutamyl-tRNA synthetase with respect to glutamic acid (K(i) = 2.8 nM) and is the best inhibitor of this enzyme. It is a weaker inhibitor of mammalian glutamyl-tRNA synthetase (K(i) = 70 nM). The corresponding 5'-O-[N-(L-pyroglutamyl)-sulfamoyl] adenosine is a weak inhibitor (K(i) = 15 microM) of the E. coli enzyme.
Links	PubMed Online version:10.1080/14756360400002007
Keywords	Adenosine/analogs & derivatives; Adenosine/chemical synthesis; Adenosine/pharmacology; Animals; Binding Sites; Binding, Competitive; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Escherichia coli/enzymology; Glutamate-tRNA Ligase/antagonists & inhibitors; Glutamate-tRNA Ligase/metabolism; Liver/enzymology; Mice; RNA, Transfer, Glu/metabolism; Substrate Specificity
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.