PMID:15883820
| Citation |
Wang, H, Li, M, Rhie, JK, Hockenbery, DM, Covey, JM, Zhang, R and Hill, DL (2005) Preclinical pharmacology of 2-methoxyantimycin A compounds as novel antitumor agents. Cancer Chemother. Pharmacol. 56:291-8 |
|---|---|
| Abstract |
The present study was designed to determine pharmacological and biochemical properties of 2-methoxyantimycin A analogs (OMe-A1, OMe-A2, OMe-A3, and OMe-A5), which are novel antitumor compounds, and provide a basis for future pharmaceutical development, preclinical evaluation, and clinical trials. |
| Links |
PubMed Online version:10.1007/s00280-004-0978-8 |
| Keywords |
Animals; Antimycin A/analogs & derivatives; Antimycin A/pharmacokinetics; Antimycin A/pharmacology; Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/pharmacology; Chromatography, High Pressure Liquid; Dogs; Drug Evaluation, Preclinical; Drug Stability; Half-Life; Humans; Injections, Intravenous; Male; Mice; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Protein Binding; Rats; Rats, Inbred F344; Species Specificity |
| edit table |
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