PMID:15883188

Citation	Osborne, MJ, Siddiqui, N, Landgraf, D, Pomposiello, PJ and Gehring, K (2005) The solution structure of the oxidative stress-related protein YggX from Escherichia coli. Protein Sci. 14:1673-8
Abstract	YggX is a highly conserved protein found only in eubacteria and is proposed to be involved in the bacterial response to oxidative stress. Here we report the solution structure of YggX from Escherichia coli determined by nuclear magnetic resonance spectroscopy. The structure of YggX displays a fold consisting of two N-terminal antiparallel beta-sheets and three alpha-helices, which shares significant structural similarity to the crystal structure of a hypothetical protein PA5148 from Pseudomonas aeruginosa. Previous studies propose YggX as an iron binding protein that is involved in cellular iron trafficking. Our data indicate that the protein alone does not bind iron in vitro, suggesting other cofactors or different conditions may be necessary for metal binding.
Links	PubMed PMC2253388 Online version:10.1110/ps.051358105
Keywords	Amino Acid Sequence; Escherichia coli/chemistry; Escherichia coli Proteins/chemistry; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Oxidative Stress; Protein Structure, Tertiary
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.