PMID:15872186

Citation	Vecerek, B, Moll, I and Bläsi, U (2005) Translational autocontrol of the Escherichia coli hfq RNA chaperone gene. RNA 11:976-84
Abstract	The conserved bacterial RNA chaperone Hfq has been shown to play an important role in post-transcriptional regulation. Here, we demonstrate that Hfq synthesis is autoregulated at the translational level. We have mapped two Hfq binding sites in the 5'-untranslated region of hfq mRNA and show that Hfq binding inhibits formation of the translation initiation complex. In vitro translation and in vivo studies further revealed that Hfq binding to both sites is required for efficient translational repression of hfq mRNA.
Links	PubMed PMC1370782 Online version:10.1261/rna.2360205
Keywords	5' Untranslated Regions/metabolism; Base Sequence; Binding Sites; Down-Regulation; Escherichia coli/genetics; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial; Host Factor 1 Protein/genetics; Host Factor 1 Protein/metabolism; Molecular Chaperones/genetics; Molecular Chaperones/metabolism; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Chain Initiation, Translational/genetics; RNA, Messenger/metabolism; Repressor Proteins/genetics; Repressor Proteins/metabolism
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