PMID:15837321

Citation	Williamson, RM, Pietersma, AL, Jameson, GB and Parker, EJ (2005) Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. Bioorg. Med. Chem. Lett. 15:2339-42
Abstract	Racemic 2-deoxyerythrose 4-phosphate was synthesized and one enantiomer of this compound was found to be a substrate for Escherichia coli 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, the first enzyme of the shikimate pathway. When the reaction was carried out in deuterium oxide, an enzyme-catalyzed regio- and stereoselective incorporation of deuterium into the product was observed.
Links	PubMed Online version:10.1016/j.bmcl.2005.02.080
Keywords	3-Deoxy-7-Phosphoheptulonate Synthase/chemistry; 3-Deoxy-7-Phosphoheptulonate Synthase/metabolism; Binding Sites; Catalysis; Deuterium; Indicators and Reagents; Isotope Labeling/methods; Models, Molecular; Protein Conformation; Sugar Phosphates/chemistry; Sugar Phosphates/metabolism
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