PMID:15817381

Citation	Hinton, DM (2005) Molecular gymnastics: distortion of an RNA polymerase sigma factor. Trends Microbiol. 13:140-3
Abstract	A recent structure obtained by nuclear magnetic resonance (NMR) spectroscopy shows that the binding of a small phage factor to the sigma(70) subunit of Escherichia coli RNA polymerase induces an unprecedented remodeling of a region of sigma(70), converting a DNA-binding helix-turn-helix into a continuous pseudohelix. This conformational change suggests how the phage factor can function both as an inhibitor and co-activator of transcription.
Links	PubMed Online version:10.1016/j.tim.2005.02.005
Keywords	Bacteriophage T4/genetics; Bacteriophage T4/metabolism; DNA-Binding Proteins/metabolism; DNA-Directed RNA Polymerases/chemistry; DNA-Directed RNA Polymerases/metabolism; Escherichia coli/chemistry; Escherichia coli/virology; Helix-Turn-Helix Motifs; Promoter Regions, Genetic; Protein Conformation; Protein Structure, Secondary; Sigma Factor/chemistry; Sigma Factor/metabolism; Transcription Factors/metabolism; Viral Proteins/metabolism
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